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Current position
Visiting Fellow BSc Hons (Monash), PhD (ANU)
Research interests
My interest is in the development of the visual system, in particular how topographic maps of the visual world are formed by the ordered connections of retinal axons in primary visual centres in the brain during development. The model used is the marsupial wallaby. Connections between the eye and the brain form postnatally in this species, permitting unrivalled access for experimental manipulation at early developmental stages not possible in placental mammals. Current work is examining the role of the transmembrane protein Ten_m3 in the establishment of topographic maps in the thalamus and midbrain (in collaboration with Dr C Leamey of the University of Sydney). This includes developmental expression studies of Ten_m3 in the retina and primary visual centres and examination of the effects of overexpression of Ten_m3 on the formation of maps using in vivo electroporation and anatomical tracing of retinal connections.
Selected Publications
More publications for CSD are available as a PDF Key Publications.
Brian Wimborne, Lauren R Marotte and Richard F. Mark.
The Brain of the Tammar Wallaby (Macropus eugenii)
in Stereotaxic Coordinates (2008).
C.A. Leamey, S.M.Ho, D.L. Flett and L.R. Marotte. Onset of connectivity in the trigeminal pathway of the wallaby: ultrastructural and in vitro electrophysiological analysis in the somatosensory cortex. Euro J Neurosci (2007) 25: 3058
D.L. Flett, C.H. Lim. S.M. Ho, R.F. Mark and L.R. Marotte. Retinocollicular synaptogenesis and synaptic transmission during formation of the visual map in the superior colliculus of the wallaby (Macropus eugenii). Euro J Neurosci (2006) 23: 3043-3050.
L.R. Marotte, M. Vidovic, E. Wheeler and S. Jhaveri. Brain Derived Neurotrophic Factor is expressed in a gradient during development of the retinocollicular map. Euro J Neurosci (2004) 20:843-847.
A.R. Pearce and L.R. Marotte. The first thalamocortical synapses are made in the cortical plate in the developing visual cortex of the wallaby ( Macropus eugenii ). J. Comp. Neurol. (2003) 461: 205-216.
M. Vidovic and L.R.Marotte. Analysis of EphB receptors and their ligands in the developing retinocollicular system of the wallaby reveals dynamic patterns of expression in the retina. Euro J Neurosci (2003) 18:1549-1558.
L.R. Marotte and X-M. Sheng. Neurogenesis and identification of developing layers in the visual cortex of the wallaby ( Macropus eugenii ). J. Comp. Neurol . (2000) 416:131-142.
J. Stubbs, A. Palmer, M. Vidovic and L.R. Marotte. Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection. Euro. J. Neurosci. (2000) 12: 3626-3636.
P.M.E. Waite, L.R. Marotte, C.A. Leamey and R.F. Mark. Development of whisker-related patterns in marsupials: factors controlling timing. Trends in Neurosci . (1998) 21:265-269.
L.R. Marotte, C.A. Leamey and P.M.E. Waite. Time course of development of the wallaby trigeminal pathway: III. Thalamocortical and corticothalamic projections. J. Comp. Neurol. (1997) 387: 194-214.
Y. Ding and L.R. Marotte. Retinotopic order in the optic nerve and superior colliculus during development of the retinocollicular projection in the wallaby ( Macropus eugenii ). Anat. Embryol. (1997) 196: 148-158.
R.F. Mark, T.C.B. Freeman, Y. Ding and L.R. Marotte. Two stages in the development of a mammalian retinocolicular projection. NeuroReport (1993) 5: 117-120.
R.F. Mark and L.R. Marotte. Australian marsupials as models for the development of the mammalian visual system. Trends in Neuroscience (1992) 15: 51-57.
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