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Current position
Research Fellow, MD (Semmelweis, Hungary), PhD (USyd)
Career Summary
I completed my medical education in 1986 in Budapest, Hungary and am a Fellow of the Association of Hungarian Ophthalmologists in 1990. I completed my PhD at The University of Sydney n 2000. Then I began a position as postdoctoral research fellow in the Department of Anatomy and Histology at The University of Sydney. During my years at USYD I have participated in and formed many scientific collaborations, including a long-standing collaborative relationship with Prof Silvia Bisti, at the Universitá di L'Aquila, Italy. At the USYD I taught neuroanatomy in both science and medical courses including the Graduate Medical Program. I have supervised honours and postgraduate students in our laboratories. In early 2003 I left The University of Sydney and took up a position at the Research School of Biological Sciences at The ANU. I am the coordinator for a neuroscience course and continue to supervise honours and postgraduate students.
I have attended many conferences both locally and overseas and have given invited lectures or seminars at national and international meetings and institutes. Results of my research have been published in high impact peer-reviewed journals. I have co-authored 4 book chapters, 2 of these being invited review chapters.
My research has focussed on degenerative diseases of the retina, from the molecular and cellular level, to the clinical. My published work has made an impact in two particular areas: (1) The role of tissue oxygen levels in the stability and degeneration of photoreceptors; and (2) the retina's ability to self-protect against stress, using the regulated expression of protective factors on the photoreceptors. In the former area I was the first to demonstrate the oxygen dependence of several forms of photoreceptor degeneration; in the latter I have shown the sites of trophic factor binding to organelles of the photoreceptor. Both lines of work enabled the formulation of new and testable hypotheses concerning the mechanisms that stabilise or destabilise photoreceptors.
My aim is to focus on the modelling of the mechanisms behind retinal degenerations and to study the effects of therapeutic interventions on these theoretical models. I have worked extensively with sufferer groups and have a good insight into the clinical consequences of my basic research. I am convinced that clinicians and scientists have to build a strong relationship to enable us to develop effective treatments.
Selected Publications
More publications for CSD are available as a PDF Key Publications
• Valter, K., Bisti, S., Gargini, C., Di Loreto S., Maccarone, R., Cervetto, L., Stone, J : Timecourse of neurotrophic factor upregulation following unilateral optic nerve section. Invest Ophthalmol Vis Sci 2005 MS 04-0657 (Article 4674)
• Stone, J., Mervin, K., Walsh, N., Valter, K., Provis, J. Penfold, P. Photoreceptor Stability and Degeneration in Mammalian Retina: Lessons from the Edge. In Philip L. Penfold, Jan Provis (eds). Macular Degeneration: Science and Medicine in Practice. Springer Verlag; 2005 :149-165.
• Stone, J., Valter, K. Roles of retinal macroglia in maintaining the stability of the retina. In: L. Hertz (ed.) Non-Neuronal Cells in the Nervous System: Function and Dysfunction. Amsterdam: Elsevier; 2003 :295-314 .
• Valter, K., Bisti, S., Stone, J.: Location of CNTFRa on photoreceptor outer segments: evidence of the site of action of CNTF in rat retina. Brain Research 2003; 985:169-175
• Valter, K., van Driel, D., Bisti, S., Stone, J.: FGFR1 expression and FGFR1-FGF-2 colocalisation in rat retina: sites of FGF-2 action on rat photoreceptors. Growth Factors 2002; 20(4):177-188
• Stone, J.; Maslim, J.; Valter-Kocsi, K.; Mervin, K.; Bowers, F.; Chu, Y.; Barnett, N.; Provis, J.; Lewis, G.; Fisher, S.K.; Bisti, S.; Gargini, C.; Cervetto, L.; Merin, S.; Pe'er, J.: Mechanisms of photoreceptor death and survival in mammalian retina (Review). Prog. Ret. Eye Res. 1999 Nov; 18(6): 689-735
• Gargini, C., Belfiore, MS., Bisti, S., Cervetto, L., Valter, K., Stone, J.: The impact of bFGF on photoreceptor function and morphology. Invest Ophthalmol Vis Sci 1999 Aug; 40(9):2088-2099
• Mervin, K., Valter, K., Maslim, J., Lewis, G., Fisher, S., Stone, J.: Limiting photoreceptor death and deconstruction during experimental retinal detachment: the value of oxygen supplementation. Am.J.Ophthalmol. 1999 Aug; 128(2):155-164
• Lewis, G., Mervin, K., Valter, K., Maslim, J., Kappel, PJ., Stone, J., Fisher, S.: Limiting the proliferation and reactivity of retinal Müller cells during experimental retinal detachment: the value of oxygen supplementation. Am.J.Ophthalmol. 1999 Aug; 128(2):165-172
Valter, K., Maslim, J., Bowers, F., Stone, J.: Photoreceptor dystrophy in the RCS rat: roles of oxygen, debris and Bfgf. Invest Ophthalmol Vis Sci 1998 Nov; 39(12):2427-2442
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