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Andrew James

Visual Sciences Group
Research School of Biological Sciences
GPO Box 475
Canberra ACT 2601
ph: (02) 6125-5441
fax: (02) 6125-3808

email: andrew.james@anu.edu.au

 

Current position

Research Officer, Visual Sciences, RSBS

Research interests

My research has been motivated by a conception of the brain as an inferential system that creates the experienced world by the interaction of incoming sensory data with prior experience and expectations. A likely implementation of this inferential system is via the feedforward and feedback connections within hierarchies of cortical areas, which I have studied using methods of feedback inactivation in the macaque visual cortex.

More recently I have focussed on the neuroimaging of activity in human visual cortical areas, for which I have developed a novel class of multifocal analysis methods using multiple linear regression in place of the usual cross-correlation. This methodology produces statistically efficient estimates, while allowing the greatest flexibility of experimental design tailored to a particular system and experimental question. These techniques are being used in multi-modal studies combining EEG and MEG recording with cortical maps obtained by corresponding multifocal FMRI analysis.

The techniques are also being applied in collaboration with Dr Ted Maddess to create new medical technologies for the diagnosis of glaucoma, using the pupillary response, and for the assessment of neurological conditions using cortical evoked potentials.

 

Selected Publications

 

Hupe JM, James AC, Payne BR, Lomber SG, Girard P, Bullier J (1998) Cortical feedback improves discrimination between figure and background by V1, V2 and V3 neurons. Nature 394:784-787.

Hupe JM, James AC, Girard P, Bullier J (2001) Response modulations by static texture surround in area V1 of the macaque monkey do not depend on feedback connections from V2. J Neurophysiol 85:146-163.

Hupe JM, James AC, Girard P, Lomber SG, Payne BR, Bullier J (2001) Feedback connections act on the early part of the responses in monkey visual cortex. J Neurophysiol 85:134-145.

James AC (2003) The pattern-pulse multifocal visual evoked potential. Invest Ophthalmol Vis Sci 44:879-890.

James AC, Veitch JG, Zareh AR, Triche T (2004) Sensitivity and specificity of five abundance estimators for high-density oligonucleotide microarrays. Bioinformatics 20:1060-1065.

James AC, Ruseckaite R, Maddess T (2005) Effect of temporal sparseness and dichoptic presentation on multifocal visual evoked potentials. Vis Neurosci 22:45-54.

Ruseckaite R, Maddess T, Danta G, Lueck CJ, James AC (2005) Sparse multifocal stimuli for the detection of multiple sclerosis. Ann Neurol 57:904-913.

Vanni S, Henriksson L, James AC (2005) Multifocal fMRI mapping of visual cortical areas. Neuroimage 27:95-105.

Vanni S, Henriksson L, Viikari M, James AC (2006) Retinotopic distribution of chromatic responses in human primary visual cortex. Eur J Neurosci 24:1821-1831

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