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Current position
Director, Research School of Biological Sciences
My career has been in neuroscience, principally in the visual pathways. Initial training was in P.O. Bishop's laboratory in the Department of Physiology, University of Sydney, gaining BSc (Med) and PhD in 1962 and 1966. After postdoctoral training was with J.C. Eccles in Chicago and at the Max Planck Institute for Psychiatry in Munich (1967-70), I was appointed a Research Fellow in Physiology in the John Curtin School for Medical Research, at the ANU (1970-5). I joined the School of Anatomy at the University of New South Wales in 1976, and served there for 11 years. The years 1987-2003 were spent as Challis Professor of Anatomy of the University of Sydney, and I rejoined the ANU in my current position in 2003. I was elected to the Australian Academy of Sciences in 1984 and served as Secretary (Biological Sciences) from 1986-1990. Sabbatical periods were spent with P. Rakic (Yale, 1979-80), M. Raff (University College London, 1984) and E. Keshet (Hebrew University of Jerusalem, 1993-4).
Early work included the development of the wholemount technique of retinal analysis, analyses (with R.W. Rodieck) of retinal receptive fields, and analyses of the nasotemporal division of the retina. In the 1970's, the study of ganglion cells was extend to the concept of parallel pathways within the visual system traced to the cortical level (with K.P. Hoffmann, B. Dreher), and analyses of the epistemology of ganglion cell classification (with M.H. Rowe). The broadest of these ideas was that of parallel processing, which I reviewed in a 1983 monograph. Influenced by the sabbatical period at Yale, the remainder of the 1980's were devoted to studies of the development of the retina (with D.H. Rappaport) and then of its blood vessels (with T. Chan-Ling). The attention to blood vessels proved to be lasting, as it drew our attention to the cell biology of the retina and the interaction between the developing retina and surrounding tissues. This evolved into the discovery, with Eli Keshet's group, of the angiogenic factor which drives retinal angiogenesis and neovascularisation, and the interaction between retinal metabolism, retinal function and vessel formation. After 10 years' work on retinal blood vessels, our attention was drawn to the stability and degeneration of photoreceptors, which also proved to be oxygen-linked. Our current range of studies (with K. Valter, J. Provis, S. Bisti) on photoreceptor stability, and the dependence of that stability of retinal oxygen levels, light exposure and mitochondrial function, followed from those insights. The study of the stability of retinal neurons has led recently to work on the stability of cortical neurons (with K. Cullen), and hence dementia.
In 2005, JS was awarded the Ludwig von Sallman Medal for Research in Vision, awarded by the International Society for Eye Research.
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These are the most recent publications over the last year if you would like to see more please click on the link for a PDF. Prof Stone's refs 1985-2003 .
More publications for CSD are available as a PDF Key Publications .
Wellard J, Lee D, Valter K, Stone J. Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia. Vis Neurosci. 2005;In press.
Valter K, Bisti S, Gargini C, Di Loreto S, Maccarone R, Cervetto L, Stone J. Timecourse Of Neurotrophic Factor Upregulation Following Unilateral Optic Nerve Section. Invest Ophthal Vis Sci . 2005;in press.
Stone J, Sandercoe TM, Provis J. Mechanisms of the Formation and Stability of Retinal Blood Vessels. In: Tombran-Tink J, Barnstable C, eds. Ocular Angiogenesis: Diseases, Mechanisms and Therapeutics . Totowa, NJ: Humana Press; 2005:In press.
Lee D, Valter K, Stone J. Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia. Visual Neuroscience . 2005;In press.
Geller S, Krowka R, Valter K, Stone J. Toxicity of hyperoxia to the retina: evidence from the mouse. RD 2004 . 2005;In press.
Cullen K, Kosci Z, Stone J. Vascular relationships of haem-rich depositis in the aging cerebral cortex. 2005 Journal of Cerebral Blood Flow Metab. 2005; in press.
Cullen K, Kosci Z, Stone J. Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging. 2005; in press.
Yu DY, Cringle S, Valter K, Walsh N, Lee D, Stone J. Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Invest Ophthalmol Vis Sci . 2004;45:2013-2019.
Walsh N, Bravo-Nuevo A, Geller S, Stone J. Resistance of photoreceptors in the C57BL/6-c2J, C57BL/6J, and BALBB/cj mouse strains to oxygen stress: Evidence of an oxygen phenotype. Current Eye Research . 2004;29:441-448.
Walsh N, Van Driel D, Lee D, Stone J. Multiple vulnerability of photoreceptors to mesopic ambient light in the P23H transgenic rat. Brain Research . 2004;1013:194-203.
Stone J, Mervin K, Walsh N, Valter K, Provis J, Penfold P. Photoreceptor stability and degeneration in mammalian retina: lessons from the edge. In: Penfold P, Provis J, eds. Macular Degeneration: Science and Medicine in Practice : Springer Verlag; 2004:149-165.
Back to top Gargini C, Bisti S, Demontis G, Valter K, Stone J, Cervetto L. ERG changes associated with retinal upregulation of trophic factors: observations following optic nerve section. Neuroscience . 2004;126:775-783.
Bravo-Nuevo A, Walsh N, Stone J. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C(2J) mouse. Invest Ophthalmol Vis Sci . 2004;45:2005-12.
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