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Current position
Senior Fellow and Group Leader, BSc Hons, PhD (UNSW)
Career Summary:
JP completed her PhD at UNSW in 1980 and took up a position as Post-doctoral Research Fellow at Sydney Eye Hospital, in the Department of Clinical Ophthalmology where she held two successive NHMRC grants looking at aspects of development of the human retina. After progressing to Research Fellow, JP competed successfully for a Lectureship in the Department of Anatomy at the University of Sydney in 1988, progressing through the level of Senior lecturer to Associate Professor in 1998. She was Co-Chair of the Neuroscience Block in the University of Sydney Medical Program and is co-ordinator of three undergraduate Neuroscience and Anatomy courses within the University of Sydney Science Faculty. She has had two periods of study overseas, including the University of Washington Seattle, Dept Biological Structure working with Professor Anita Hendrickson and supported by a Senior Fellowship from the international organization, Research to Prevent Blindness. In late 2003 JP left the University of Sydney to take up a Senior Fellowship in RSBS.
JP's research career has been dedicated to achieving a better understanding of the biology of the human retina and in particular the fovea, through direct investigation of adult human postmortem tissues, human fetal tissues and using appropriate animal models. The retina of humans and monkeys is unique amongst mammals, having a highly specialized central region - the fovea centralis - which mediates high visual acuity, is of fundamental importance to our success as a species, and is highly vulnerable to degenerative disease. Over a period of 25 years JP devised studies that describe the timecourse of differentiation of the human neural retina, the development and arrangement of its immune system and vasculature, the relationship of these events to specialization and formation of the foveal depression and, more recently, the associated molecular events. In addition, she have been involved in studies analyzing the disease process of age-related macular degeneration (AMD), the significance of immunogical mechanisms, neovascularization of the macula in AMD and breakdown of the blood-retinal barrier. As a result JP has a broad perspective on how the crucial, central (macular / foveal) part of the primate retina is likely to have evolved, how it develops, what the functional constraints are and why it is vulnerable to degeneration.
The majority of JP's publications are in the field of retinal development, her contribution to the field being recognized in the most recent editions of both Wolff's Anatomy and the 3 volume series "Retina" edited by Steven Ryan. Work describing apoptosis in the developing human retina has been acknowledged as a key observation in understanding the significance of cell death in retinal development. JP is a member of the Scientific Advisory of Regenera Pty Ltd. She has been keynote speaker and Chairperson at several international meetings, including the International Neuro-Ophthalmology Conference, ICER and ARVO; has authored 56 publications (1979 - 2004) in international refereed journals, 3 book chapters and one edited volume; supervised 8 Honours students and 4 higher degree candidates to completion. Back to top
Selected Publications
More publications for CSD are available as a PDF Key Publications .
Georges, P., Madigan, M.C. and Provis, J.M. (1999) Apoptosis during development of the human retina: Relationship to foveal development and retinal synaptogenesis J. Comp. Neurol. 413: 198-208
Sandercoe, T., Madigan, M., Billson, F.A., Penfold, P.L. and Provis, J.M. (1999) Astrocyte proliferation during development of the human retinal vasculature Exp Eye Res. , 69 : 511-523.
Provis, J.M., Sandercoe, T. and Hendrickson, AE. (2000) Astrocytes and perifoveal vessels define the foveal rim during primate retinal development Investigative Ophthalmology and Visual Science 41: 2827 - 2836.
Penfold, P.L., Wen, L. Madigan, M.C., Gillies, M.C., King, N.J.C. and Provis, J.M. (2000) Triamcinolone acetonide modulates permeability and ICAM-1 expression of the ECV304 cell line: Implications for Macular Degeneration. J. Clin. Exp. Immunol. 121 : 458-465.
Zhu, M., Madigan, M.C., van Driel, D., Maslim, J., Billson, FA., Provis, J.M. and Penfold, P.L. (2000) The human hyaloid: Cell death and vascular regression. Exp. Eye Res. 70 :767-776.
Gariano RF, Provis JM, Hendrickson AE. (2000) Development of the foveal avascular zone. Ophthalmology . 107 :1026 .
Penfold, P.L., Madigan, M.C., Gillies, M. and Provis, J.M. (2001) Immunological and aetiological aspects of AMD Progress in Retinal & Eye Research; 20 :385-414.
Provis, J.M (2001) Development of primate retinal vasculature Progress in Retinal & Eye Research 20 : 799 - 821 [Invited review].
Penfold, P.L., Wen, L. Madigan, M.C., King, N.J.C. and Provis, J.M. (2002) Modulation of permeability and adhesion molecule expression of human choroidal endothelial cells. Invest Ophthalmol Vis Sci . 43 :3125 - 3130.
Sandercoe, T., Geller, S., Hendrickson, A., Stone, J. and Provis, J. (2003) VEGF Expression During Formation of the Monkey Fovea: Evidence of Mechanisms Controlling Formation of the Perifoveal Capillary Plexus J. Comp. Neurol 462 : 42-54.
Wallcott, JC and Provis, JM (2003) Müller cells express the neuronal progenitor cell marker nestin in both differentiated and undifferentiated human foetal retina. Clinical and Experimental Ophthalmology 31 :246-249.
Cornish, EEG, Natoli, RC, Hendrickson, AE and Provis, JM. (2004) Differential distribution of fibroblast growth factor receptors (FGFRs) on foveal cones: FGFR-4 is an early marker of cone photoreceptors Molecular Vision 10 1-4. January 8.
Cornish, EEG, Xiao, M, Zhantao Yang Z, Provis, JM, Hendrickson, AE. (2004) The role of opsin expression and apoptosis in determination of cone types in human retina. Experimental Eye Research 78 : 1143-1154
Cornish, EEG, Hendrickson, AE and Provis, JM. (2004) Distribution of Short Wavelength Sensitive Cones in Human Fetal and Postnatal Retina: Early Development of Spatial Order and Density Profiles Vision Research 44 : 2019-2026
Book Chapters
Greenwood, J., Penfold, P.L. and Provis, J.M. (2000) Evidence for the Intrinsic Innervation of Retinal Vessels: Anatomical Substrate of Autoregulation in the Retina? In: Nervous Control of the Eye G. Burnstock and A. Sillito (Eds). Harwood Academic.
Penfold, PL. Wong, J. van Driel, D, Provis, JM and Madigan, MC Immunology & Age-related Macular Degeneration (2004) In: Age-Related Macular Degeneration PL Penfold and JM Provis (Eds). Springer-Verlag (in press)
Stone, J, Mervin, K, Walsh, N, Valter, K, Provis, JM and Penfold, PL (2004) Photoreceptor Stability And Degeneration In Mammalian Retina: Lessons From The Edge . In: Age-Related Macular Degeneration. PL Penfold and JM Provis (Eds). Springer-Verlag (in press)
Edited Volume
P.L. Penfold and J.M. Provis (Eds) 2004 Age-Related Macular Degeneration. Springer Verlag (in press) - 14 chapters, 22 international authors)
More Abstracts 2004 Key publications
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