Current position
Senior Fellow and Head of Group
Research interests
The research themes of my laboratory are: 1. Identifying new biologically active signal molecules in plants (peptides, flavonoids); 2. Identifying bioactive molecules that bridge between plant and animal systems (with Chris Parish); 3. Identifying the functional roles of secreted proteins and peptides in plants; 4. Biofuels production.
My collaboration with Professor Parish at the John Curtin School has led to a major breakthrough. We have identified a series of small molecules that are biologically active in plants and that positively and negatively modulate angiogenesis in mammals. These molecules may find utility in cancer, cardiovascular disease and wound healing. The work has been patented.
I am working with an ANU wide team to initiate research to address basic science issues around using selected microalgae to produce biofuels and biomass and to establish strategies to address global climate change.
Student opportunities
Projects for prospective students can be found here. Scholarships are available for Domestic and International students - as well as potential support from the ARC Centre of Excellence for Intergrative Legume Research (CILR) in which I am a Chief Investigator.
Post Graduate Supervision (since 2000)
PhD supervisor: Siria Natera, Angela Morris, Lucia Kusumawati (AusAID scholarship), Gabriel James.
PhD advisor: Peta Holmes, John Stefaniak, Greg Budulovic, Jianyu Wen, Brett Furguson (U. Tasmania), Ryan Farquarson (U. Adelaide).
Post Doctoral Fellows: Angela Morris (2005), Charles Buer (2006-2007).
Honours students: Scott Taylor (2003), Peta Holmes (2004), Chris Dawson (2006-7).
International student: Nguyen Dang Thu Cuc (University of Queensland 2006).
External and ANU activities
I regularly speak at International congresses (e.g. Nitrogen Fixation, International Society for Molecular Plant Microbe Interactions, Plant and Animal Genome conferences). I was extended a special invitation in 2004 to visit the Centre of the Investigation of Nitrogen Fixation in Cuernavaca, Mexico as part of their Visiting Professor program.
I undertook a sabbatical at the Australian Proteomics Analysis Facility (APAF) at Macquarie University in October 2005 with Professor Mark Baker.
I am on the Board of Directors of IS MPMI Journal, the Managerial Board of the Australian Proteomics Computational Facility and a member of several ANU/RSBS committees overseeing student quality and scholarship rankings. I am on the ANU Biomolecular Resource Facility (BRF) users committee.
Publications
Publication record
I have published over 76 refereed papers (including 21 since 2000). I have been invited to speak at 27 International or local conferences with 14 invitations in the past 5 years often with expenses (partly) subsidised. I have also published 32 book chapters/invited conference contributions and have contributed to over 100 conference poster presentations. My research papers have attracted >2600 citations at >37 citations/paper (ISI Web of Knowledge) including 6 citation classics (>100 citations). I have 16 papers with > 50 citations. According to ISI Web of Knowledge, papers with over 50 citations are in the top 1% within their field. My H index is 30. My work is recognised internationally as demonstrated by publication in high citation impact journals such as the Plant Journal (citation impact 6.96); J Bacteriology (4.2); Proteomics (6.1); Molecular Plant Microbe Interactions (4.1); Nature (29.3); EMBO J (10.05); Journal of Proteome Research (6.9); Journal of Biological Chemistry (5.8); Annual Review of Phytopathology (7.6); and Genome Biology (9.7). My work has been featured on Journal covers 6 times.
Selected publications
Kusumawati L, Imin N and Djordjevic MA (2008) Characterisation of the secretome of suspension cultures of Medicago species reveals proteins important for defence and development. Journal of Proteome Research (in press)
Miyahara A, Hirani TA, Oakes M Kereszt A, Kobe B, Djordjevic MA and Gresshoff PM (2008) Soybean nodule autoregulation receptor kinase phosphorylates two kinase-associated protein phosphatases in vitro. Journal of Biological Chemistry (in press)
Scott PT, Pregelj L, Chen N, Hadler JS, Djordjevic MA andGresshoff PM (2008) Pongamia pinnata: An Untapped Resource for the Biofuels Industry of the Future. Plant Energy Biology 1: 1-10.
Buer CS, Muday GK and Djordjevic MA (2008) Implications of long-distance flavonoid movement in Arabidopsis thaliana. Plant Signaling and Behavior 3: 415-417.
Wilton J, Djordjevic MA, Cordwell S, Minion FC, Walker MJ and Djordjevic SP (2008) Mhp493 is a novel heparin binding surface protein of Mycoplasma hyopneumoniae. Molecular Microbiology (In press).
Djordjevic MA, Oakes M, Hocart C, Li D and Gresshoff PM (2007) Analysis of secreted proteins present in Glycine max xylem sap. Journal of Proteome Research. 6: 3771-3779.
Buer CS, Muday GK and Djordjevic MA (2007) Flavonoids are differentially taken up, converted to downstream products, and transported long distances in Arabidopsis. Plant Physiology 145: 478-490.
Zhang K, McKinlay C, Hocart CH and Djordjevic MA (2006) The Medicago truncatula small protein proteome and peptidome. J. Proteome Research. 5: 3355-3367
Djordjevic M and Buer C (2006) Is there gold at the top of the beanstalk? Genome Biology. 7 318.
Morris AC and Djordjevic MA (2006) The Rhizobium leguminosarum biovar trifolii strain ANU794 induces novel developmental responses on the subterranean clover cultivar Woogenellup. Molecular Plant Microbe Interactions. 19: 471-479.
Schlaman HRM, Olsthoorn MMA, Harteveld M, Dorner L, Djordjevic MA Tomas-Oates JE and Spaink HP (2006) The production of species-specific highly unsaturated fatty acyl containing LCOs from Rhizobium leguminosarum bv. trifolii is stringently regulated by nodD and acts in the nodE-nodL intergenic region. Molecular Plant Microbe Interactions. 19: 215-226
Djordjevic MA (2004) Sinorhizobium meliloti metabolism in the root nodule: a proteomic perspective. Proteomics. 4: 1859-72. (Journal Cover)
Rolfe BG, Djordjevic M, Chen H-C, Hocart CH, Weiller G, Mathesius U. Proteomic analysis of bacterial systems. In: Methods in Microbial Ecology Manual, 2nd edition, Kowalchuk, GG; de Bruijn, FJ; Head, IM; Akkermans, AD; van Elsas, JD (eds), Kluwer Academic Publishers, pp 1–12.
Reeve WG, Tiwari RP, Guerreiro N, Stubbs J, Dilworth MJ, Glenn AR, Rolfe BG, Djordjevic MA and Howieson JG (2004). Probing for pH-regulated proteins in Sinorhizobium medicae using proteomic analysis. J. Mol. Microbiol. Biotechnol. 7: 140-7.
Djordjevic SP, Cordwell SJ, Djordjevic MA, Wilton J and Minion FC (2004). Proteolytic processing of the Mycoplasma hyopneumoniae cilium adhesin. Infect. Immun. 72: 2791-802.
Rolfe BG, Mathesius U, Djordjevic M, Weinman J, Hocart C, Weiller G and Bauer WD (2003) Proteomic analysis of legume-microbe interactions. Comparative and Functional Genomics 4: 225-228.
Djordjevic MA, Chen H-C, Natera, SHA, van Noorden G., Menzel C, Taylor S, Geiger O and Weiller G (2003) A global analysis of protein expression profiles in Sinorhizobium meliloti: Discovery of new genes for nodule occupancy and stress adaptation. Molecular Plant-Microbe Interactions.16: 508-524.
Roddam, LF, Lewis-Henderson, WR and Djordjevic, MA (2002) Two novel chromosomal loci influence cultivar-specific nodulation failure in the interaction between strain ANU794 and Subterranean clover cv. Woogenellup. Functional Plant Biology 29: 473-483.
Morris AC and Djordjevic MA (2000) Proteome analysis of cultivar specific interactions between Rhizobium leguminosarum biovar trifolii and the subterranean clover cultivar Woogenellup. Electrophoresis. 21: 586-598, 2001.
Natera SHA, Guerreiro N, Djordjevic MA (2000) Proteome analysis of differentially displayed proteins as a tool for the investigation of symbiosis. Molecular Plant-Microbe Interactions. 13: 995-1009.
Mathesius U, Weinman JJ, Rolfe BG and Djordjevic MA (2000) Rhizobia can induce nodules in white clover by “hijacking” mature cortical cells activated during lateral root development. Molecular Plant-Microbe Interactions 13: 170-182.
Guerreiro N, Djordjevic MA and Rolfe BG (1999) Proteome analysis of the model microsymbiont Sinorhizobium meliloti: Isolation and characterisation of novel proteins. Electrophoresis 20: 818-825.
Mathesius U, Bayliss C, Weinman JJ, Schlaman HRM, Spaink HP, Sautter C, Rolfe BG, McCully ME and Djordjevic MA (1998) Flavonoids synthesized in cortical cells during nodule initiation are early developmental markers in white clover. Molecular Plant Microbe Interactions 11: 1223-1232.
Mathesius U, Schlaman HRM, Spaink HP, Sautter C, Rolfe BG and Djordjevic MA (1998) Auxin transport inhibition precedes root nodule formation in white clover roots and is regulated by flavonoids and derivatives of chitin oligosaccharides. The Plant Journal 14: 23-43.
Guerreiro N, Stepkowski T, Rolfe BG and Djordjevic MA (1998) Determination of plasmid-encoded functions in Rhizobium leguminosarum biovar trifolii using proteome analysis of plasmid-cured derivatives. Electrophoresis 19: 1972-1979.
Djordjevic MA, Mathesius U, Arioli T, Weinman JJ, and Gärtner E. (1977) Chalcone synthase gene expression in transgenic subterranean clover correlates with localised accumulation of flavonoids. Australian Journal of Plant Physiology 24: 119-132.
Guerreiro N, Redmond JW, Rolfe BG, and Djordjevic, MA (1997) New Rhizobium leguminosarum flavonoid-induced proteins revealed by proteome analysis of differentially displayed proteins. Molecular Plant-Microbe Interactions 10, 506-516.
Larkin PJ, Gibson JM, Mathesius U, Weinman JJ, Gärtner E, Hall E, Tanner GJ, Rolfe BG and Djordjevic M.A. (1996) Transgenic white clover. Studies with the auxin-responsive promoter, GH3, in root gravitropism and secondary root development. Transgenic Research. 5: 325-335.
Lawson CGR, Rolfe BG and Djordjevic MA (1996). Rhizobium inoculation induces condition-dependent changes inthe flavonoid composition of root exudates in Trifolium subterraneum. Australian Journal of Plant Physiology. 23:93-101.
de Boer MH and Djordjevic MA (1995). Inhibition of infection thread development in the cultivar-specific interaction of Rhizobium and subterranean clover is not caused by a hypersensitive response. Protoplasma 185: 58-71.
Lawson CGR, Djordjevic MA, Weinman JJ, and Rolfe BG. (1994) Rhizobium inoculation and physical wounding results in the rapid induction of the same chalcone synthase copy in Trifolium subterraneum. Molecular Plant-Microbe Interactions 7(4): 498-507.
McKay IA and Djordjevic MA (1993) Production and excretion of Nod metabolites by Rhizobium leguminosarum biovar trifolii are disrupted by environmental factors associated with reduced nodulation in the field. Applied and Environ. Microbiol. 59: 3385-3392.
Djordjevic MA and Weinman JJ (1991). Factors determining host recognition in the clover-Rhizobium symbiosis. Australian Journal of Plant Physiology. 18: 543-557.
Lewis-Henderson WR and Djordjevic MA (1991) A cultivar specific interaction between Rhizobium leguminosarum biovar trifolii and subterranean clover is conditioned by nodM, other bacterial cultivar specificity genes and a single recessive host gene. J. Bacteriol. 173: 2791-2799.
Lewis-Henderson WR and Djordjevic MA (1991) Cultivar
specificity in the symbiosis between Trifolium subterraneum and
Rhizobium leguminosarum biovar trifolii is determined by a complex
interaction between bacterial nod genes. Plant Molecular Biology.
16: 515-526.
Gray JX, Djordjevic MA and Rolfe BG (1990) Two genes that regulate exopolysaccharide production in Rhizobium sp. strain NGR234: DNA sequences and resultant phenotypes. J. Bacteriology 172: 193-203.
Spaink HP, Weinman JJ, Djordjevic MA, Wijffelman CA, Okker RJH and Lugtengerg BJJ (1989) Genetic analysis and cellular localization of the Rhizobium host-specificity determining NodE protein. E. M. B. O. Journal. 8: 2811-2818.
Djordjevic MA, Gabriel DW and Rolfe BG (1987) Rhizobium: the refined parasite of legumes. Annv. Rev. Phytopathology 25: 339-358.
Djordjevic MA, Redmond JW, Batley M, and Rolfe, BG (1987) Clovers secrete specific phenolic compounds which either stimulate or repress nod gene expression in Rhizobium trifolii. EMBO Journal 6: 1173-1179.
Patents
Nodulation inducing factors U5141745 (1986)
Nodulation gene promoter U5484718 (1986)
Modulators of angiogenesis (PCT lodged 31 March, 2006). AU2006/000432
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