Current position
Senior Fellow and Head of Group
Research interests
The research themes of my laboratory are: 1. Identifying new biologically active signal molecules in plants (peptides, flavonoids); 2. Identifying bioactive molecules that bridge between plant and animal systems (with Chris Parish); 3. Identifying the functional roles of secreted proteins and peptides in plants; 4. Biofuels production.
My collaboration with Professor Parish at the John Curtin School has led to a major breakthrough. We have identified a series of small molecules that are biologically active in plants and that positively and negatively modulate angiogenesis in mammals. These molecules may find utility in cancer, cardiovascular disease and wound healing. The work has been patented.
I am working with an ANU wide team to initiate research to address basic science issues around using selected microalgae to produce biofuels and biomass and to establish strategies to address global climate change.
Student opportunities
Projects for prospective students can be found here. Scholarships are available for Domestic and International students - as well as potential support from the ARC Centre of Excellence for Intergrative Legume Research (CILR) in which I am a Chief Investigator.
Post Graduate Supervision (since 2000)
PhD supervisor: Siria Natera, Angela Morris, Lucia Kusumawati (AusAID scholarship), Gabriel James.
PhD advisor: Peta Holmes, John Stefaniak, Greg Budulovic, Jianyu Wen, Brett Furguson (U. Tasmania), Ryan Farquarson (U. Adelaide).
Post Doctoral Fellows: Angela Morris (2005), Charles Buer (2006-2007).
Honours students: Scott Taylor (2003), Peta Holmes (2004), Chris Dawson (2006-7).
International student: Nguyen Dang Thu Cuc (University of Queensland 2006).
External and ANU activities
I regularly speak at International congresses (e.g. Nitrogen Fixation, International Society for Molecular Plant Microbe Interactions, Plant and Animal Genome conferences). I was extended a special invitation in 2004 to visit the Centre of the Investigation of Nitrogen Fixation in Cuernavaca, Mexico as part of their Visiting Professor program.
I undertook a sabbatical at the Australian Proteomics Analysis Facility (APAF) at Macquarie University in October 2005 with Professor Mark Baker.
I am on the Board of Directors of IS MPMI Journal, the Managerial Board of the Australian Proteomics Computational Facility and a member of several ANU/RSBS committees overseeing student quality and scholarship rankings. I am on the ANU Biomolecular Resource Facility (BRF) users committee.
Publications
Publication record
I have published over 76 refereed papers (including 21 since 2000). I have been invited to speak at 27 International or local conferences with 14 invitations in the past 5 years often with expenses (partly) subsidised. I have also published 32 book chapters/invited conference contributions and have contributed to over 100 conference poster presentations. My research papers have attracted >2600 citations at >37 citations/paper (ISI Web of Knowledge) including 6 citation classics (>100 citations). I have 16 papers with > 50 citations. According to ISI Web of Knowledge, papers with over 50 citations are in the top 1% within their field. My H index is 30. My work is recognised internationally as demonstrated by publication in high citation impact journals such as the Plant Journal (citation impact 6.96); J Bacteriology (4.2); Proteomics (6.1); Molecular Plant Microbe Interactions (4.1); Nature (29.3); EMBO J (10.05); Journal of Proteome Research (6.9); Journal of Biological Chemistry (5.8); Annual Review of Phytopathology (7.6); and Genome Biology (9.7). My work has been featured on Journal covers 6 times.
Selected publications Djordjevic MA, Redmond JW, Batley M, and Rolfe, B.G. (1987).
Clovers secrete specific phenolic compounds which either stimulate
or repress nod gene expression in Rhizobium trifolii. EMBO Journal
6: 1173-1179.
Djordjevic, M.A., Gabriel, D.W. and Rolfe, B.G. (1987). Rhizobium:
the refined parasite of legumes. Annv. Rev. Phytopathology 25:
339-358.
Spaink H. P., Weinman, J. J., Djordjevic, M. A., Wijffelman,
C. A., Okker, R. J. H., Lugtengerg, B. J. J. (1989). Genetic analysis
and cellular localization of the Rhizobium host-specificity determining
NodE protein. E. M. B. O. Journal. 8: 2811-2818.
Gray, J. X., Djordjevic, M. A. and Rolfe, B. G. (1990). Two genes
that regulate exopolysaccharide production in Rhizobium sp. strain
NGR234: DNA sequences and resultant phenotypes. J. Bacteriology
172: 193-203
Lewis-Henderson W. R. and Djordjevic, M. A. (1991). Cultivar
specificity in the symbiosis between Trifolium subterraneum and
Rhizobium leguminosarum biovar trifolii is determined by a complex
interaction between bacterial nod genes. Plant Molecular Biology.
16: 515-526
Lewis-Henderson W. R. and Djordjevic, M. A. (1991). A cultivar
specific interaction between Rhizobium leguminosarum biovar trifolii and subterranean clover is conditioned by nodM, other bacterial
cultivar specificity genes and a single recessive host gene. J.
Bacteriol. 173: 2791-2799
Djordjevic M. A. and Weinman J. J. (1991). Factors determining
host recognition in the clover-Rhizobium symbiosis. Australian
Journal of Plant Physiology. 18: 543-557
McKay I. A. and Djordjevic M. A. (1993) Production and excretion
of Nod metabolites by Rhizobium leguminosarum biovar trifolii are disrupted by environmental factors associated with reduced
nodulation in the field. Applied and Environ. Microbiol. 59: 3385-3392.
Lawson CGR, Djordjevic MA, Weinman JJ, and Rolfe BG. (1994) Rhizobium inoculation and physical wounding results in the rapid induction
of the same chalcone synthase copy in Trifolium subterraneum.
Molecular Plant-Microbe Interactions 7(4): 498-507.
de Boer M.H., and Djordjevic M. A. (1995). Inhibition of infection
thread development in the cultivar-specific interaction of Rhizobium and subterranean clover is not caused by a hypersensitive response.
Protoplasma 185: 58-71
Lawson, C. G. R., Rolfe, B.G., and Djordjevic M. A. (1996). Rhizobium inoculation induces condition-dependent changes inthe flavonoid
composition of root exudates in Trifolium subterraneum. Australian
Journal of Plant Physiology. 23:93-101
Larkin P.J., Gibson, J.M., Mathesius, U., Weinman, J.J., Gartner,
E., hall, E., Tanner, G.J., Rolfe, B.G. and Djordjevic M.A. (1996)
Transgenic white clover. Studies with the auxin-responsive promoter,
GH3, in root gravitropism and secondary root development. Transgenic
Research. 5: 325-335
Guerreiro, N, Redmond, JW, Rolfe, BG, and Djordjevic, MA. (1997)
New Rhizobium leguminosarum flavonoid-induced proteins revealed
by proteome analysis of differentially displayed proteins. Molecular
Plant-Microbe Interactions 10, 506-516
Djordjevic MA, Mathesius U, Arioli T, Weinman JJ, and Gärtner
E. (1977) Chalcone synthase gene expression in transgenic subterranean
clover correlates with localised accumulation of of flavonoids.
Australian Journal of Plant Physiology 24: 119-132.
Guerreiro, N. Stepkowski, T. Rolfe, B.G., and Djordjevic, M.A.
(1998). Determination of plasmid-encoded functions in Rhizobium
leguminosarum biovar trifolii using proteome analysis of plasmid-cured
derivatives. Electrophoresis 19: 1972-1979
Mathesius U, Schlaman HRM, Spaink HP, Sautter C, Rolfe BG, and
Djordjevic MA. (1998) Auxin transport inhibition precedes root
nodule formation in white clover roots and is regulated by flavonoids
and derivatives of chitin oligosaccharides. The Plant Journal
14: 23-43.
Mathesius U, Bayliss C, Weinman JJ, Schlaman HRM, Spaink HP,
Sautter C, Rolfe BG, McCully ME, and Djordjevic MA. (1998) Flavonoids
synthesized in cortical cells during nodule initiation are early
developmental markers in white clover. Molecular Plant Microbe
Interactions 11: 1223-1232.
Guerreiro, N., Djordjevic, M.A. and Rolfe, B.G. (1999) Proteome
analysis of the model microsymbiont Sinorhizobium meliloti: Isolation
and characterisation of novel proteins. Electrophoresis 20: 818-825
Mathesius, U, Weinman, J. J., Rolfe B. G., Djordjevic, M. A.
2000. Rhizobia can induce nodules in white clover by “hijacking”
mature cortical cells activated during lateral root development.
Molecular Plant-Microbe Interactions, 13, 170-182.
Natera, S. H. A., Guerreiro N., Djordjevic, M. A., 2000 Proteome
analysis of differentially displayed proteins as a tool for the
investigation of symbiosis. Molecular Plant-Microbe Interactions.
13: 995-1009.
Morris, A. C. and Djordjevic. 2000. Proteome analysis of cultivar
specific interactions between Rhizobium leguminosarum biovar trifolii and the subterranean clover cultivar Woogenellup. Electrophoresis.
21: 586-598, 2001
Roddam, LF, Lewis-Henderson, WR and Djordjevic, MA. (2002) Two
novel chromosomal loci influence cultivar-specific nodulation
failure in the interaction between strain ANU794 and Subterranean
clover cv. Woogenellup. Functional Plant Biology 29: 4730483
M. A. Djordjevic, H. C. Chen, S. Natera, G. Van Noorden, C. Menzel,
S. Taylor, C. Renard, O. Geiger, the Sinorhizobium DNA Sequencing
Consortium, and G. F. Weiller. (2003) A Global Analysis of Protein
Expression Profiles in Sinorhizobium meliloti: Discovery of New
Genes for Nodule Occupancy and Stress Adaptation. Molecular Plant
Microbe Interactions 6: 508-524.
Patents
Nodulation inducing factors U5141745 (1986)
Nodulation gene promoter U5484718 (1986)
Modulators of angiogenesis (PCT lodged 31 March, 2006). AU2006/000432
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