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Current position
Postdoctoral Research Fellow, RSBS
Research interests
My research interests include using comparisons of distantly
related mammals to deduce the evolution of the mammalian sex chromosomes.
I am interested in the evolutionary history of male-specific sex
determination and spermatogenesis genes on the human Y chromosome,
and how they have acquired their male-specific functions. I am
also interested in the origin of sex and reproduction related
genes and genes which may impact on cognitive development, especially
those that lie on the human X chromosome.
Selected Publications
Kirby, PJ, Waters, PD, Delbridge, ML, Svartman, M, Stewart, A,
Nagai, K, Graves, JAM. (2002) Cloning and mapping of platypus
SOX2 and SOX14: Insights into SOX group B evolution. Cytogenet.Cell
Genet. (in press)
Graves, J.A.M and Delbridge, M.L. (2001). The X - a sexy chromosome.
Bioessays 23:1091-1094.
Waters, P.D., Duffy, B, Delbridge, M.L., Frost, C. and Graves,
J.A.M. (2000). Comparative mapping reveals that the human Y chromosome
is largely derived from an autosomal region recently added to
the sex chromosomes. Cytogenet.Cell Genet. 92: 74-79.
Delbridge, M.L., Lingenfelter, P.A., Disteche, C.M. and Graves,
J.A.M. (1999). The candidate spermatogenesis gene family RBMY,
has a homologue on the X chromosome. Nature Genetics 22: 223-224.
Delbridge, M.L. and Graves, J.A.M. (1999). Mammalian Y chromosome
evolution and the male-specific functions of Y borne genes. Rev.
Reprod. 4: 101-109.
Graves, J.A.M, Delbridge, M.L. and Pask, A. (1998). X-Y homology
and the evolution of sex determining and spermatogenesis genes
on the Y chromosome Amer. J. Hum. Genet. 63:A50.
Graves, J.A.M., Cook, S.I., Glas, R., O'Neill, R.J.W., Pask,
A. and Delbridge, M.L. (1998). Genes involved in male reproduction
as targets for biocontrol of the brushtailed possum. Biological
Control of Possums. Royal Society of New Zealand, Miscellaneous
series 45: 62-72.
Delbridge, M.L. Ma, K. Bhasin, S., Subbarao, M., Cooke, H. and
Graves, J.A.M. (1998). Evolution of mammalian hnRNPG and its relationship
with the putative azoospermia factor RBM. Mamm. Genome 9:168-170.
O'Neill, R.J.W., Brennan, F.E., Delbridge, M.L., Crozier, R.H.
and Graves, J.A.M. (1998). De novo insertion of an intron into
the mammalian sex determining gene, SRY. Proc. Natl. Acad. Sci.
USA.. 95: 1653-1657.
Delbridge, M.L., Harry, J.L., Toder, R., O'Neill, R.J.W., Ma,
K., Chandley, A.C. and Graves, J.A.M. (1997). A human candidate
spermatogenesis gene RBM1 is conserved and amplified on the marsupial
Y chromosome. Nature Genet. 15:131-136.
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