Diplomo
Version 1.03 (1995)
An interactive computer graphics application
for windows that uses the distance plot principle in a new and
powerful approach to phylogenetic analysis. DIPLOMO compares different
distance measures with each other by displaying them as a scatter
plot. It then helps one instantly identify all individual comparisons
within the plot.
What can be seen in Diplomo
plots?
- The trends that occur in different distance measures and hence
in the mutational changes that gave rise to the individual taxa
compared.
- The grouping of taxa with similar characteristics.
- How different distance measures correlate.
What can be learned from
a Diplomo analysis? Depending on the distance measures used many
different questions can be addressed with a DIPLOMO analysis,
some typical examples are:
- Whether different (groups of) taxa exhibit specific mutational
constraints or preferences.
- Whether a group of taxa that have particular characteristics
when examined by one pair of distance measures also stand out
when different distance measures are applied. As an example,
DIPLOMO would readily tell one, whether sequences that show
a relatively high proportion of synonymous mutations also show
a relatively high proportion of transitional changes.
- Whether a particular distance measure is appropriate for deriving
a phylogenetic tree.
- Whether the relative speed of the molecular clock within members
of a phylum is constant and hence whether the evolutionary time
span that can be assigned to one part of a tree can be extrapolated
to other parts of that tree.
- Whether trees derived from different data subsets or obtained
using different algorithms vary.
Reference publication
Weiller G. F. & Gibbs A. J. (1995) DIPLOMO:
The tool for a new type of phylogenetic analysis. CABIOS
11:5 535-540
System requirements:
DIPLOMO was designed using the Zinc (tm) interface library and
runs in text mode as well as under various graphics modes under
MS-DOS.
Minimal system:
IBM compatible computer; 480 K RAM;Floppy disk.
Desired system:
IBM compatible computer with Intel 80286 processor or better;(optional
math co-processor is used if installed); VGA graphics compatible
video card; 600 K RAM; Hard disk; mouse.
Download a copy
of the program
and readme.
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